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3. 毒理学
3. TOXICITY
 
 
Sr. No. TYPE / NAME OF THE STUDY EPA, OPPTS OECD  EEC 
ACUTE 
1 Acute oral rat  870-1100  420/423/425  EU B.1 
2 Acute oral mice  870-1100  423 EU B.1 
3 Acute dermal rat  870-1200  402 EU B.3 
4 Acute inhalation rat (Full / Limit)  870-1300  403 EU B.2 
5 Dermal irritation rabbit  870-2500  404 EU B.4 
6 Mucous membrane irritation rabbit  870-2400  405 EU B.5 
7 Skin sensitization - Buehler method  870-2600 406 EU B.6 
8 Skin sensitization - M & K   870-2600 - 406 EU B.6 -
9 Local Lymph Node Assay in Mice    429  
CHRONIC 
10 28 days oral rat  870-3050  407 EU B.7 
11 28 days dermal rat  870-3200  410 EU B.9 
12 28 days dermal rabbit  870-3200  410 EU B.9 
13 90 days oral rat  870-3100  408 EU B.26 
14 14 days inhalation rat  - 412 -
15 28 days inhalation rat  - 412 EU B.8 
16 90 days inhalation rat  870-3465  413 EU B.29 
GENOTOXICITY         
17 Ames test  870-5100  471 B.14 
18 In vitro mammalian gene mutation test  870-5300  476 B.17 
19 In vitro human lymphocyte  870-5375  473 B.10 
20 Chromosomal aberration in mice  870-5385  475 B.11 
21 Micronucleus test in mice  870-5395  474 B.12 
REPRODUCTION         
22 Teratology /Prenatal development in rats  830-3200  414 B.31 
23 Teratology /Prenatal development in rabbits  830-3200  414 B.31 
24 One generation in rats  - 415 B.34 
25 Two generation in rats  870.63 416 B.35 
26 Development Neurotoxicity in Rats  - 422 -
CARCINOGENICITY         
27 Carcinogenicity in rats  870.42 451 B.32 
28 Carcinogenicity in mouse  870.42 451 B.32 
29 Combined chronic carcinogenicity in rats 870.43 453 B.33 
30 Chronic toxicity in rats  870.41 452 B.30 
AQUATIC         
31 Alga growth inhibition test  - 201 C.3 
32 48 h. Acute immobilization Daphnia magna    202 C.2 
33 Acute fish tox-Common Carp (Semi static)    203 C.1 
34 Acute fish tox- Rainbow trout (Semi static)    203 C.1 
35 Reproduction test - Daphnia magna    211 C.20 
36 A.I. Method validation for Ecotox Studies    - -
TERRESTRIAL         
37 Avian dietary toxicity test - Japanese quail  --------- 205 -
38 Avian dietary toxicity test - Mallard duck    205 -
39 Avian reproduction test - Japanese quail    206 -
40 Avian acute oral toxicity - Japanese quail    Setac  -
41 Acute toxicity - earthworm (Eisenia foetida) Earthworm reproduction toxicity/ Earthworm    207 C.8 
42 subchronic toxicity    222 -
43 Acute toxicity-honeybee oral(Apis mellifera)    213 C.16 
44 Acute tox honeybee-contact(Apis mellifera)    214 C.17 
45 Acute toxicity to honeybee - oral & contact    - EPPO. 
 
 
 
 
 
 

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